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Interestingly, preclinical data has suggested that compounds thought to target downstream processes of ATXN3 aggregation have also an effect on the primary loss of PQC mechanisms, namely citalopram, creatine, and trehalose, making them great contenders for translation [148, 164, 236]

Therefore, the rate of gastric emptying plays a key role in determining alcohols absorption rate (5)

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Furthermore, the question whether Vit B12 should be considered as symptomatic treatment in PD or as a disease modifying therapy remains triggering and unresolved
