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Chemiosmosis is carried out by Complex V of OXPHOS, the multi-unit enzyme ATP synthase that produces ATP by utilizing the energy of the proton gradient established by ETC [19]

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Consistently, the Princeton III Consensus Recommendations for the management of ED and CVD indicate that incident ED has a similar or even greater predictive value for CVD, when compared to traditional risk factors exerting a direct detrimental impact on the endothelial function [13]