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How do GLP-1s affect motivation and reward in the brain

GIPR agonists In contrast to the results inferred from the obesity-promoting effects of GIP, it has been shown that transgenic mice overexpressing GIP exhibit a significant decrease in weight gain after ingestion of an HFD, suggesting that chronic elevation of GIP levels well above physiological concentrations may exert a centrally mediated suppressive effect on appetite [124]

doi: 10.1016/0006-8993(94)90160-0 101 Stoa-BirketvedtGWaldumHLVonenBFlorholmenJ

How GLP-1 Drugs Can Affect Fertility and Birth Control December 08, 2025 University Hospitals Rainbow Babies & Children's Experts in Children's Health You may have heard stories of surprise Ozempic babies that occur after starting weight loss drugs