eli lilly lawsuit tirzepatide FDA's decision creates uncertainty for patients—and leads to a Eli Lilly Reaches $13.5 Million

(2.2 ) If additional glycemic control is needed, increase the dosage to 1 mg once weekly after at least 4 weeks on the 0.5 mg dose

Adverse Reactions/Side Effects The following adverse reactions are discussed elsewhere: Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen [see Warnings and Precautions (5.2)] Hypoglycemia [seeWarnings and Precautions (5.3)] Hypoglycemia Due to Medication Errors [see Warnings and Precautions (5.4)] Hypersensitivity Reactions [see Warnings and Precautions (5.5)] Hypokalemia [see Warnings and Precautions (5.6)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trial of another drug and may not reflect the rates observed in practice

doi: 10.3390/jpm14070768

What this adds up to clinically: GLP-1s are best understood as treating the underlying metabolic disease, not just as a weight loss intervention