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The addition of oligofructose as a prebiotic to the diet in ob/ob mice significantly increases plasma GLP-1, colonic L cell abundance, and colon proglucagon mRNA levels 73,74 , and GLP-2R antagonism blunts the anti-inflammatory effects of this prebiotic treatment 73
In the Dartmouth-led study, patients first lost weight using the GLP-1 drug Zepbound
A 2023 study found that 67% of IBD patients reported either no gastrointestinal worsening or actual symptom improvement on GLP-1 therapy, though individual responses vary significantly based on disease activity and genetic factors