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Interestingly, however, genetic evidence supports repurposing of GLP-1 RAs for prevention of heart failure 54 and a recent meta-analysis of the GLP-1 RA cardiovascular outcome trials identified an 11% reduction in hospital admission for heart failure with GLP-1 RA treatment

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By activating both receptors, oxyntomodulin increases energy expenditure, reduces appetite, promotes weight loss, and improves glucose tolerance, showcasing the therapeutic potential of this dual mechanism [79]

Rising cAMP levels then activate protein kinase A (PKA), which phosphorylates calcium-handling proteins in the heart muscle