is glp-1 a biologic Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP -1 despite enzymatic cleavage of its C-terminal end Is Ozempic a Biologic? -
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These include situations where metformin is ineffective, contraindicated, or when patients fail to reach their target glycemic control despite treatment with metformin and other medications

Kruse R, Vienberg SG, Vind BF, Andersen B, Hojlund K (2017) Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes

While GLP-1 degradation is unaffected by kidney function, the clearance of both GLP-1, and to a greater extent its inactive metabolites, is delayed in patients with renal insufficiency [184]
