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Genetic variation in the GLP-1 receptor (GLP1R rs6923761), glucose-dependent insulinotropic peptide receptor (GIPR), and obesity-risk genes like FTO rs9939609 and MC4R rs17782313 may influence how your body responds to appetite-suppressing medications

Serious side effects: Any differences

Here's a breakdown of how Semaglutide interacts with some common medications: Paracetamol: Semaglutide may slightly delay the absorption of paracetamol, but the overall amount absorbed remains the same

Before starting semaglutide, your healthcare provider should evaluate your fatigue through appropriate blood work, sleep studies, or specialist referral to rule out treatable conditions