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Additionally, caffeine's stimulant effects on gut motility can contribute to diarrhoea in some individuals
Staying well hydrated prevents constipation
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To obtain the pulsatile release from MNs patches over a predetermined time period, the PSR-MNs contain 4 pixels (each pixel is a small MN patch of 1 1 cm 2 ) which were fabricated using either PVP or different molecular weight PLGAs for the shell
