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The use of specific cAMP analogues and ryanodine or IP 3 receptor antagonists demonstrated that Epac sensitizes the ryanodine receptors and PKA the IP 3 receptors [85,87,91]
Like albiglutide, it has a lower probability of hypoglycemia and no significant weight loss
However, insights from cardiovascular and kidney outcome trials in individuals with T2D have shifted current guidelines toward a disease-modification approach
