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Even though it may seem as if the ketogenic diet has entered our collective consciousness only recently, its actually more than 100 years old, says the National Library of Medicine

The mean percentage change in weight at week 72 was 15.0% (95% confidence interval [CI], 15.9 to 14.2) with 5-mg weekly doses of tirzepatide, 19.5% (95% CI, 20.4 to 18.5) with 10-mg doses, and 20.9% (95% CI, 21.8 to 19.9) with 15-mg doses

In fact, its probably the biggest barrier to increasing use of this medication. For physicians, another large challenge when prescribing GLP-1RA medications includes lack of clinical guidelines for offlabel prescribing

Department of Health and Human Services, FDA is charged with overseeing the safety of many products