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GLP-1s are incretin-based agents that amplify glucose-stimulated insulin secretion, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety

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However, in the subgroup of patients with BMI 25 kg/m 2 , the exenatide subgroup significantly increased the number of heavy drinking days compared to the placebo group

11 Sitagliptin is a minor substrate for the cytochrome P450 system, and drug interactions are limited to concomitant use with digoxin