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Short-acting GLP-1RA (e.g., exenatide, lixisenatide) more prominently delays gastric emptying [70] but generally produces more modest and earlier-plateauing weight loss [71]
Moreover, incretin-based therapies have also been proven beneficial on obesity-related comorbidities, such as knee osteoarthritis (KOA), obstructive sleep apnea (OSA) syndrome, and MASLD
Regarding collateral effects, the most commonly reported were gastrointestinal-related (diarrhea, nausea, vomiting, constipation) mainly occurring during the dose escalation period
