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Dennett SL, Boye KS, Yurgin NR The impact of body weight on patient utilities with or without type 2 diabetes: a review of the medical literature
The MHRA guidance indicates no formal dose adjustment is necessary based solely on renal function, but clinical caution is advised in severe renal impairment/ESRD
most evidence comes from case reports and small observational studies rather than randomized controlled trials
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