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Preventing hair loss while taking semaglutide or tirzepatide Prevention is always easier than treatment

Evolutionarily, we were designed to eat as much and as fast as we can, because there was no way to preserve food. Extra calories are stored as fat, but as soon as you start losing weight, your body starts thinking somethings wrong, Suri explains, which, hormonally, makes it harder to lose weight. The body responds by increasing appetite and slowing metabolism, and the hormones that regulate feelings of hunger kick into high gear, to drive your body weight back to the set-point range. GLP-1s and GIPs help override those hunger signals while improving the insulin receptivity that allows your body to burn fat

GCGR activation, represented in green, is unique in that glucagon receptors are robustly expressed on hepatocytes, enabling direct liver-directed metabolic effects - a mechanistic feature absent from both GLP-1R and GIPR signaling

Indeed, the fold change in expression of selected genes is not impressive, and thus may reduce the strength of our observations