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Some compounds present in TS are processed and metabolically activated by oxidoreductases, such as cytochrome P450, after which hydrosoluble electrophilic molecules bind to the genome leading the production of covalent and stable complexes with nitrogenated bases, known as DNA adducts [135,136] which can lead to mutations and cancer [137]

Protocol Design for Surveillance of Risk Factors of Non-Communicable Diseases During the COVID-19 Pandemic: An Experience from Iran STEPS Survey 2021

Because of the diminished need for trained labor, families of slaves on cotton and rice plantations would often remain together, bought and sold as complete packages

It is important to acknowledge that sugars contribute to only a fraction of the total concentrations of volatile toxicants and carcinogens in cigarette smoke, with significant amounts of these harmful agents being generated from the pyrolysis of the tobacco filler or other product ingredients