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Research shows that children of smokers can develop oral melanin pigmentation through passive exposure to secondhand smoke
Ultimately, since irinotecan-TACE is a locoregional therapy that can be repeated for progressive or new lesions or followed up by other locoregional or systemic therapies, early response and disease control should not be neglected. Moreover, the authors emphasise the potential for irinotecan-TACE to be combined with other treatment strategies to either intensify the liver-directed treatment or target extrahepatic disease
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