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it was John Rolfe who in 1612 obtained Spanish seeds, or Nicotiana tabacum , from the Orinoco River valleyseeds that, when planted in the relatively rich bottomland of the James River, produced a milder, yet still dark leaf that soon became the European standard
Recruiters, screeners and data collectors from the research firm participated in an in-person training in each of the survey cities
In vitro analyses have shown various degrees of cytotoxic and inflammatory responses across different nicotine pouches brands, possibly influenced by flavorings (39, 40, 42)
