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Influisce sui sistemi serotoninergici, dopaminergici, oppioidi e GABAergici

If the rate constants for these reactions at several different storage conditions are determined, a predictive model can be used to estimate the time needed for the reaction to proceed to an unacceptable level under any storage conditions

Therefore, V d is better understood not as a physical volume but as an index of partitioning, indicating the degree to which a drug is sequestered in extravascular tissues

This is usually not enough to cause significant degradation over the life of a single vial, but combined with other stress factors, it contributes