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Nevertheless, it has also been demonstrated that glucose deficiency, activation of the system Xc system, high expression of SLC7A11, elevated NADP+/NADPH ratio, extensive NADPH consumption, cystine accumulation, and decreased GSH levels collectively drive ferroptosis [97]
Meta-analysis: glutathione-S-transferase allelic variants are associated with alcoholic liver disease
The rate of reaction depends on the cellular GSH level and the ratio of GSH to H 2 O 2 concentrations [100]
