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The glucagon receptor activation leads to a direct increase in energy expenditure, something neither Tirzepatide nor Cagrilintide can do (at least not as effectively)

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The net result is more time spent growing and less time spent shedding

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These effects are associated with increased expression of the cyclin-dependent kinase inhibitors (CDKNs) p21 and p27, which are negative cell cycle regulators (Pandey et al., 2010)

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