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Description
Several studies in murine models have demonstrated that DZN disrupts the activity of antioxidant enzymes, particularly glutathione peroxidase, which plays a critical role in renal metabolism [43]
FGF21 is an Akt-regulated myokine

Phase I metabolism alters the chemical structure of the drug by functionalization reactions which introduce a polar functional group onto the molecule

Nat Rev Immunol (2014) 14:2435
