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Description
One such well-studied modification is by the covalent attachment of ubiquitin(s) to the epsilon amino side-chains of internal lysines known as ubiquitination [71]

This mechanism is thought to account for the rewarding effects of 9 -THC and other cannabinoid drugs, and is also likely to be a prominent mechanism through which eCBs contribute to brain mechanisms of reward

doi: 10.2147/JPR.S123045

Pretreatment with a Src inhibitor abolished these effects in HUVEC culture, placing Src upstream of the caveolin-1-eNOS step in the proposed cascade