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Manipulation of intracellular GSH pools by supplementation with GSH precursors was found to block induction of JNK activity by methylating agents [26] Similarly p53 function has been reported to be redox sensitive, primarily through in vitro modification of its cysteine residues [27]

3.2 New insight of cellular programmed death associated with metabolic reprogram in PCa Emerging research underscores the intricate crosstalk between metabolic reprogramming and regulated cell death pathways in PCa, where hypoxia and nutrient deprivation within the TME drive adaptive survival mechanisms (197)
