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Upon ligand interaction, these regions undergo a Venus flytrap-like conformational closure, ensuring high-affinity binding and precise gating of the receptor channel (Lam et al
Liu, J., Yang, X., Yu, S
GPX4-IN-24 suppresses GPX4 enzymatic activity, disrupts redox homeostasis, drives lipid peroxidation, promotes lipid peroxidation, and induces ferroptosis
This chemotherapy resistance was reversed upon MET inhibition using crizotinib
