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Many go as far as intentionally injecting neurotoxins multiple times a year (aka botox)

This indicates that alterations in intestinal epithelium integrity caused by genetic or environmental factors contributes to the translocation of luminal microbes that can become immunogenic when delocalised from their GI niche (Fine et al

However, in our previous study with 127 non-Hunner type IC/ BPS patients and 28 controls, urine CXCL10 levels were not only significantly increased in IC/BPS patients but also correlated with the glomerulation grade and maximal bladder capacity 11

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