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Conversely, the downregulation of NRF2 by FTH (ferritin heavy chain), NQO1 (NAD(P)H quinone oxidoreductase-1), and HO-1 (heme oxygenase1) amplified the sensitivity to ferroptosis in HCC [92]

313 Cuproptosis evasion in tumor progression and therapeutic resistance Despite the presence of a cuproptosis-mediated tumor suppression mechanism, tumors can still arise and progress uncontrollably, suggesting the existence of evasion mechanisms against cuproptosis in cancer cells (Fig

In our simulations, non-methylated DNA (nDNA), center-methylated DNA (cDNA) and fully-methylated DNA (fDNA) were subjected to a stretching force directed along the helical axis

But endothelial nitric oxide production declines over time