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Future studies should perform dose-ranging (including lower total doses) and schedule optimization (eg, 3 days/week vs 6 days/week, and intermittent vs continuous dosing) to determine the minimal effective exposure for survival and frailty outcomes while improving translational feasibility and tolerability

We measured by Western blot the percentage of Tpx1 and OxyR oxidation after 1 min of applying increasing extracellular concentrations of H 2 O 2 (Fig

doi: 10.1016/j.biopsych.2017.03.002 135 RobertsCJStuhrKLHillardCJ

Here, we discuss key findings pertinent to our current discussion, that is direct neurotransmitter effects on adult NSCs and pharmacological studies that have attempted to augment adult neurogenesis in vitro and in vivo