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The essential elements of Alzheimers disease

Liby Kt, Royce Db, Risingsong R, et al

Complement activation leads to interaction with antigens, providing a potent signal through binding to B cell receptors, which lowers the activation threshold and enhances the antibody response, while activating macrophages and cytokines, such as interleukins (IL)-8 and IL-1 [103]

For instance, HMGB1 can regulate calcium levels through a TLR4/ROS-dependent pathway, leading to calcium leakage from the sarcoplasmic reticulum, a reduction in the amplitude of calcium transients, and decreased cardiomyocyte contractility, which can further aggravate the pathological processes in the heart [307]