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doi: 10.1001/jama.2015.18318
M.HoylandJ
Orphan drug status typically includes benefits such as extended market exclusivity, tax credits for clinical research, and reduced regulatory fees
This is due to the fact that in CGD the production of the ROS, hydrogen peroxide, is deficient and so these catalase-positive microorganisms can defeat the limited levels of ROS produced by phagocytic cells
