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Description
Multi-omics integration was conducted to reveal core regulatory networks, and mechanistic validation focused on the expression of Nrf2, HO-1, and GPX4
10.1021/acs.est.6b06259 189 YuS.WeiD.ShiL.AiY.ZhangP.WangX
The copper component serves as an essential cofactor for lysyl oxidase and lysyl hydroxylase, enzymes critical for proper collagen cross-linking and stability
This results in reduced -catenin expression, inhibition of its nuclear translocation, and decreased expression of downstream oncogenic targets such as cyclin D1 and VEGF
