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Diabetic retinopathy complications: rapid improvement in glycemic control may worsen diabetic retinopathy acutely

The DIO mice were randomized into three treatment groups balanced by baseline body weight and body composition (fat and lean mass) measures

Structurally, cagrilintide incorporates several amino acid substitutions relative to native IAPP that confer resistance to amyloid fibril formationa known limitation of unmodified amylin analogues in experimental settingsas well as a C18 fatty diacid side chain that facilitates albumin binding and extends the compound's half-life