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Ultimately, while MS is a chronic inflammatory disorder accompanied by fatigue and depression [63], CoQ10 has neuroprotective and antioxidant properties, and hence decreases pro-inflammatory cytokines and protects the brain cells and neurons against central neurotoxic damages [64]

Mast cells also release histamine and inflammatory cytokines that further loosen these junctions, compounding the damage

MHP is associated with increased O 2 consumption and electron transport chain activity (Doherty et al

Topical application is limited by the stratum corneum barrier, with near-zero penetration through intact skin (Li et al., 2015)