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LiXLiuDZhaoLWangLLiYChoKet alTargeted depletion of monocyte/macrophage suppresses aortic dissection with the spatial regulation of MMP-9 in the aorta

During pro-inflammatory states, Schwann cells release the cytokines (e.g., TNF, IL-1, IL-6) and small molecules (e.g., ATP) that contribute to the initiation of NP

Reactive oxygen species, primarily H 2 O 2, generation, was measured in HCM (7,500 cells per well, 10 M DOX, 4.4 M, B-017/negative control peptide, 4 h), HCF (80,000 cells per well, 500 nM STS, 52 M B-017, 1 h), HEK293 (80,000 cells/ per well, 500 nM STS, 52 M B-017, 1 h) and MCF-7 cells (80,000 cells per well, 500 nM STS, 52 M B-017, 1 h) using the DCFDA/H 2 DCFDACellular ROS Assay Kit (Abcam, ab113851), according to the manufacturers instructions