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This trial also found a trend (p=0.07) for a lower rate of disease progression with topical citicoline (91)
We also include a full B-complex, including methyl B12 and methyl folate given their critical role in brain and nervous system function
Extensive research into muscle dysfunction in CFS/ME has shown that patients often exhibit a pathological overreliance on this anaerobic metabolism, even during incredibly low-level, everyday exertion
on BDI and MADRS, effects favored ALC but varied among studies
