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Contribution of Lys256 and Lys413 to the mIDH2 reaction To determine the K m and k cat values of isocitrate and NADP + for the two most affected mutants, K256Q and K413Q, we conducted a steady-state kinetics analysis

FRDA iPSC-derived neurons have unaltered ability to differentiate into neuronal cells although showing some disease hallmarks, including delayed maturation and mitochondrial dysfunction (Maheshwari et al., 2023)

de Sa Junior PL, Camara DAD, Porcacchia AS, Fonseca PMM, Jorge SD, Araldi RP, Ferreira AK
For example, IL-1, IL-6, IL-8, and TNF are some of the pro-inflammatory cytokines that were increased during ME/CF [109]
