what is melanotic macules macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Oral melanotic macule - Stock

Treatment of oxLDL with purified PON1 markedly decreases its ability to induce endothelial cell activation and monocyte binding (264)

This indicates a specific effect on appetitive sexual behavior, suggesting its potential use in treating female sexual arousal disorders

It had semi-opaque pigmentation that applied evenly but pulled into my lip lines noticeably

In MM patients, 24% of tumors exhibit copy number loss of CDKN2A ( CDK4 , CCND1 , and MDM2 are amplified in 28%, 18%, and 19% of samples respectively, and TP53 mutations occur in 9.0% of MMs ( CDKN2A loss than MM, MM tends to show a greater frequency of CCND1 and CDK4 amplification (120, 122), implying CDK4 blocking agents may achieve a desired anti-tumor effect on MM