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To increase the selectivity of covalent inhibitors, the alkyne moiety is incorporated as an electrophilic reagent

Conclusion Copper lies at the core of a fundamental biological tradeoff: it is essential for redox biochemistry yet becomes rapidly cytotoxic when it escapes tight intracellular homeostasis control

Identification of a preventative therapy would allow for continued use of these efficacious antibiotics and chemotherapeutics without the devastating ototoxic consequences that accompany their use

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