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Compounds including arginine, fagomine, 1-deoxynojirimycin, and 1,4-dideoxy-1,4-imino-D-arabinitol in the extract reduced the levels of IL-6 and TNF- secreted by LPD-induced RAW264.7 and BMDM cells as well as inhibited the phosphorylation of p38 MAPK, ERK, and JNK in BMDM and activated ERK and JNK signaling in RAW264.7 cells [79]

& Kung, J

Therapeutic approaches for oxidative stress in dry eye disease The therapeutic approaches for oxidative stress in DED aim to limit the production of ROS and to enhance the antioxidant defense mechanisms of the ocular surface

As compared to those of guanine and cytosine, adenine modifications have been the most extensively investigated