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Eli Lilly completed a 48 week phase 2 trial on a selective amylin agonist, eloralintide

Amylin is a 37-amino-acid peptide that the pancreas co-secrets with insulin and promotes satiety, slow gastric emptying, and suppresses glucagon after a meal

Drowsiness after injection is normal and expected

Antidote: N-acetylcysteine (NAC) within 810 hours Symptoms of overdose: Nausea/vomiting RUQ abdominal pain Elevated liver enzymes Jaundice Hepatic failure (severe) Advantages Safe in pregnancy and breastfeeding Suitable for patients with ulcers or NSAID allergy Widely available and affordable Key Points to Remember Do not exceed the maximum daily dose Watch for combinations with other cold or pain medications containing paracetamol Use cautiously in liver disease To view or add a comment, sign in Carbonic Anhydrase Inhibitors (CAIs) - Diuretics Need a quick breakdown of Carbonic Anhydrase Inhibitors