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Description
In addition to directly obtaining TMAO from fish and seafood, it is more commonly produced by the gut microbiota through the conversion of foods rich in choline, L-carnitine, and ergothioneine (e.g., red meat, eggs, and mushrooms) (164)

Neuron 90, 675691

This phenomenon, known as ER stress, arises when the cells intrinsic quality control mechanisms fail to cope with the protein-folding burden

In contrast, isoleucine and valine largely serve as metabolic substrates and display weaker activation of translational signaling
