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Description
In macrophages, the activity of JNK and p38 are negatively regulated by Mkp-1, a dual specificity protein phosphatase (40, 44, 48, 65), and attenuated Mkp-1 activity could enhance both JNK and p38 activities

Impact of AREDS in a developing country 5 years after publication of the study

In these trials, when assessing the efficacy and safety of gantenerumab ( 19 ) in participants with early (prodromal to mild) AD, the drug showed little clinical benefit in slowing cognitive decline, potentially due to limited clearance of amyloid plaques, with 5.0% participants experienced amyloid-related imaging abnormalities-effusion (ARIA-E) related side effects
doi: 10.1016/j.mehy.2021.110543 110
