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In vivo studies have confirmed that DSF and Cu have synergistic effects with TMZ and improve survival in mice with in situ GBM tumors (Lun et al., 2016)

Funding The author declares financial support was received for the research, authorship, and/or publication of this article

Tight regulation of CDO activity may facilitate maintenance of relatively low steady-state Cys concentrations so that Cys is available for essential functions (e.g., protein, CoA, glutathione, and H 2 S synthesis) while also preventing high Cys concentrations, which could be toxic

This results in the production of more protective enzymes (antioxidants) such as glutathione, catalase, and superoxide dismutase