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As the results from our Principal Component Analyses clearly suggested the presence of systematic methylation differences between the different conditions in a high number of replicates, our findings illustrate the potential of DNA methylation analysis for the establishment of epigenetic markers to monitor and facilitate the successful adaptation of CHO cells to new media

Metformin is a popular drug used to target oxphos throughout these studies, and while it is FDA approved for management of diabetes, it is known for having many off-target effects