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In certain cancers, CD44v isoforms are considered to be tumor progression promoters [3338], while in other cancers, they may be involved as tumor suppressors [26, 3944]

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The combination of senolytics and senomorphics could rejuvenate both bone and muscle tissue by eliminating senescent cells and modulating the inflammatory environment that promotes bone resorption and muscle wasting.215 Such therapies could reduce the risk of fractures, improve muscle strength, and enhance mobility in the elderly.216 Cancer: Cellular senescence is a double-edged sword in cancer

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