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In multiple myeloma, CB-839 as a single agent was not efficient, but the main purpose of the research was the discovery of the mechanisms that help to overcome resistance to carfilzomib

Singlet oxygen may react with various cellular components, however, preferentially interacts with conjugated double bonds of polyunsaturated fatty acids

Experimental and human metabolic literature demonstrates that GH promotes fatty acid mobilization, shifts substrate preference toward fat oxidation, and alters carbohydrate-lipid partitioning during fasting and metabolic stress states, making GH secretagogue systems useful tools for investigating adipose tissue signaling, fuel selection, and the endocrine regulation of energy metabolism [8]
10.1111/resp.12984 Respirology 59 HtooA