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10.1111/j.1432-1033.1974.tb03386.x 70 HvidbergV.ManieckiM

At a certain blood concentration of cortisol this protection is ostensibly achieved and the cortisol exerts negative feedback to the hypothalamic release of CRF and the pituitary release of ACTH (negative feedback)

It can show you if fillers will give a partial improvement, say 50% better, or closer to a full improvement
