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In the case of folate and B12, there are no reports of direct toxicity of either excess folate or B12 consumption [12], however, there are growing concerns about an upper limit of supplementation
Although VEGF-D is a potential biomarker for ramucirumab in colorectal and hepatocellular carcinoma, earlier studies did not identify it as a useful biomarker for patients with GC (156)
it has been shown to efficiently penetrate the lens (Hipkiss 2000
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