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As organisms have developed into complex, multicellular lifeforms, some have evolved to use the O 2 binding affinity of globin proteins to facilitate O 2 transport as part of a centralized circulatory system

doi: 10.7759/cureus.6610 83 van HeerdeMJBiermannKZondervanPEKazemierGvan EijckCHJPekCet al

JIMD Rep 2015;15:13-27

Shi, Y., Downes, M., Xie, W., Kao, H.Y., Ordentlich, P., Tsai, C.C., Hon, M., Evans, R.M
