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While the Arrestin and Clathrin boxes-bound peptides adopt an extended conformation, the W-box displays a 310 helix fold to bind in the pocket
For example, using an APP transgenic mouse model of AD, Cherny et al
Importantly, Nrf2 is a necessary transcription factor that regulates the cellular oxidative stress reaction and also controls Fe 2+ , which is manifested as an inhibition of ferroptosis (27, 66)
13,14 However, when inflammation overreacts, it will inevitably trigger autoimmune diseases
